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1.DON'T TAKE IT IF YOU'RE GOING TO LIE.
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Two rare and related diseases leave their sufferers with no fingerprints. Now scientists may have cracked the genetic code behind the inherited ailments.
Researchers at the Technion-Israel Institute of Technology in Haifa and Thomas Jefferson University in Philadelphia report that defects in the protein keratin 14 may be responsible for both diseases, known as Naegeli syndrome and dermatopathia pigmentosa reticularis (DPR).
The lack of fingerprints can cause vexing social problems, which are magnified because few people have heard of the condition.
Cheryl Maynard of Fairfax, Virginia, is part of the fifth generation of her family to have inherited DPR from her mother's side.
"My father was in the military and he had top-secret clearances," she recalled.
"We moved a lot, and everywhere we went they'd say, What do you mean your wife doesn't have fingerprints? What do you mean that you have kids without fingerprints?"
Maynard has personally experienced many fingerprint-related snafus, often related to employment.
She works as a flight attendant and noted that a standard background check by the U.S. Federal Aviation Administration, which took about 2 weeks for most of her peers, took 14 weeks in her case.
"I applied for work at a jail facility, and they were naturally fingerprinting people who were going to be employees," she said.
"I kept hearing, Of course you have fingerprints. And five or six different technicians were telling one another, You're doing this wrong, let me do this. I have to tell them I was born without them."
"Things like that are a problem," Maynard said. "It has delayed me [from] getting jobs."
Unable to Sweat
For the handful of people without fingerprints the physical impacts are few. Maynard has normal feeling in her fingers, though the lack of fingerprints deprives her of some grip, which makes dealing cards or turning pages more difficult.
But the lack of fingerprints is not the diseases' only, or even most serious, impact.Patients also experience thickening of their palms and soles of their feet. They suffer from anomalies in the development of their teeth, hair, and skin, where pigmentation can appear patchy and uneven.
Most dangerously, they have skin issues that can inhibit their ability to sweat normally.
"That's the only really serious manifestation as far as potential harm," said professor Eli Sprecher of the Technion-Israel Institute. Sprecher is co-author of the study that discusses the conditions in the October issue of the American Journal of Human Genetics.
"Because they cannot evacuate heat, they can develop heat stroke."
Maynard added that this problem has always made sports a trial.
"I swam competitively as a kid, but some parents would always ask why I was sitting on the side of the pool. My mom would have to tell them, Even though the water is cold, she's overheated from swimming."
As an adult Maynard is careful to stay hydrated, keep ice packs handy, and use air conditioning for most of the year.
Link to "Suicidal Cells," Cancer?
Unfortunately for those who suffer such ailments, a cure is not at hand.
But the protein culprit, first identified by Technion graduate student Jennie Lugassy, could be the clue to cracking more common and dangerous diseases.
According to Gabriele Richard, study co-author and geneticist at Thomas Jefferson University, "apparently keratin 14 is very important for developing skin in the fetus and creating the fingerprints."
Researchers are also pondering the protein's connection with programmed cell death—information that could someday help with many skin disorders.Programmed cell death, a form of cellular suicide, is the way that cells typically expire when the useful phase of their existence is complete. The process is often disabled in cancer cells, allowing them to live and proliferate.
"It looks as if the disease is associated with the inability of the cell to produce normal levels of keratin 14," Sprecher said.
"It would be interesting to determine if keratin 14 has a role in cell death."
1. To remove a bandage painlessly, saturate the bandage with vodka. The Solvent dissolves adhesive.
2. To clean the caulking around bathtubs and showers, fill a Trigger-spray bottle with vodka, spray the caulking, let set five Minutes and wash clean. The alcohol in the vodka kills mold and mildew.
3. To clean your eyeglasses, simply wipe the lenses with a soft, clean cloth dampened with vodka. The alcohol in the vodka cleans the glass and kills germs.
4. Prolong the life of razors by filling a cup with vodka and letting Your safety razor blade soak in the alcohol after shaving. The vodka disinfectsthe blade and prevents rusting.
5. Spray vodka on vomit stains, scrub with a brush, and then blot dry.
6 Using a cotton ball, apply vodka to your face as an astringent to cleanse the skin and tighten pores.
7. Add a jigger of vodka to a 12-ounce bottle of shampoo. The alcohol cleanses the scalp, removes toxins from hair, and stimulates the growth of healthy hair.
8. Fill a sixteen-ounce trigger-spray bottle and spray bees or wasps to kill them.
9. Pour one-half cup vodka and one-half cup water in a Ziploc freezer bag and freeze for a slushy, refreshable ice pack for aches, pain or black eyes.
10. Fill a clean, used mayonnaise jar with freshly packed lavender flowers, fill the jar with vodka, seal t he lid tightly and set in the Sun for three days. Strain liquid through a coffee filter, then apply the tincture to aches and pains.
11. To relieve a fever, use a washcloth to rub vodka on your chest and back as a liniment.
12. To cure foot odor, wash your feet with vodka.
13. Vodka will disinfect and alleviate a jellyfish sting.
14. Pour vodka over an area affected with poison ivy to remove the Urushiol oil from your skin.
15. Swish a shot of vodka over an aching tooth Allow your gums to absorb some of the alcohol to numb the pain.
Francisco ("Pancho") Villa "Black Jack" Ketchum, notorious train robber Voltaire (attributed), when asked by a priest to renounce Satan Norman Douglas Terry Kath, rock musician in the band Chicago Transit Authority as he put the gun he was cleaning to his head and pulled the trigger. Robert F. Kennedy, to his wife directly after he was shot and seconds before he fell into a coma. |
Groucho Marx Karl Marx, asked by his housekeeper what his last words were Franklin Delano Roosevelt, who died of a massive cerebral hemorrhage Richard Feynman Pablo Picasso Marco Polo, Venetian traveller and writer Jean Cocteau Joan Crawford. This comment was directed towards her housekeeper who began to pray aloud. Edgar Allan Poe Del Close, improvisor, teacher and comedian, died 1999 Grover Cleveland, US President, died 1908 Kurt Cobain (in his suicide note), Lead singer for American grunge band Nirvana, referencing a song by Neil Young. 30-year-old anchorwoman Christine Chubbuck, who, on July 15, 1974, during technical difficulties during a broadcast, said these words on-air before producing a revolver and shooting herself in the head. She was pronounced dead in hospital fourteen hours later. Thomas Edison General William Erskine, after he jumped from a window in Lisbon, Portugal in 1813. Rajiv Gandhi, Indian Prime Minister, to his security staff minutes before being killed by a suicide bomber attack. Crawford Goldsby, aka Cherokee Bill, when asked if he had anything to say before he was hanged. Christopher Grace, an actor who killed himself during a matinee performance of Greece Che Guevara Harry Houdini Victor Hugo Aldous Huxley To his wife. She obliged and he was injected twice before his death. Pope John Paul II Winston Churchill, before slipping into a coma and dying nine days later. Fernando Pessoa, Portuguese poet Mother Teresa Archimedes Frida Kahlo George Sanders, Actor General John Sedgwick, Union Commander in the U.S. Civil War, who was hit by sniper fire a few minutes after saying it George Bernard Shaw Frank Sinatra Socrates Oscar Wilde |
Tip #1
Tip #2
Don't try to say everything.
There are probably a lot of things you have on your mind, and you need to take some time and sort them out. Decide what is most important to say and leave out things that don't matter. Decide now what you want your readers to come away with after reading your note. Eliminate those things that distract from that point.
Tip #3
Handwrite your note if you can.
A handwritten note is a lot more personal. However, if you are worried your letter will not be understood, or you are physically not able to write it by hand don't worry about it. The important thing is that you get your message across.
Tip #4
Be natural.
Write the way you would speak. A good suicide note is personal, not formal. Don't get out the thesaurus and look for the biggest words you can find. Be yourself.
Tip #5
Avoid cliché's
Filling your note with phrases like "Goodbye cruel world" and "no one understands me" will make your note feel less like your thoughts and more like a form letter. Too many cliché's and it can look like you are just going through the motions or that you are leaving a note because you feel that you should, but without having anything to say. If you want to say something but it sounds too cliché, try to re-word it a little.
Tip #6
In general, use first person.
It creates a sense of intimacy and makes it easier for a reader to see things from your point of view, if you want to use a different viewpoint, be sure that you stick to it throughout your whole note.
Tip #7
Don't use your note like a will.
You might want your best friend to get your stereo but your suicide note is not the place to express that. If you want to leave certain things to certain people you should setup a will ahead of time. Just because you write it down does not make it legal, and it can be easily dismissed by the claim that you were not of sound mind when you wrote it.
Taking the time to set up a will will also help keep you from giving away your stuff in the months/weeks/days before the suicide. That's one of the most obvious indications that you are thinking about killing yourself and will likly get you "saved", or at least make the process more difficult.
Tip #8
Be Honest.
Your note will be one of the last things you give the world to judge you by. If you include things that others can disprove, it can discount the entire note. Besides, there is not much reason for lying at this point, is there?
Tip #9
Don't reveal your methods.
This is most important when taking poisons and pills. Telling everyone what you took just makes it easier for them to give you the treatments needed to revive you. Alternately, you do not want someone to find the note that details which bridge you're jumping off of before you get that chance to jump. They might be able to stop you. People will find out how you did it once the autopsy reports come in anyway.
Tip #10
Don't say anything you might regret.
There is always a chance that you will be found and "rescued". Suicide notes are not the place to rip into people, give away other's secrets, or confess crimes. The last thing you want is to end up in a hospital bed, facing the people who read something you would never have told them while alive.
Tip #11
Don't try to persuade the reader.
You do not want to spend your time trying to convince the reader that you are right. In most cases nothing you can say will change they way they feel. Your purpose is to express your point of view. It doesn't matter if the reader shares your point of view or not, only that they understand it.
Tip #12
Proofread your note.
Re-read your note at least twice. It's easy to make a simple mistake that distracts from the overall feel of the note. When reading over your note, there are a lot of things to look for. It's better to read it several times, looking for something different each time then to try to remember it all while reading it over once.
Make sure the point you wanted to get across when you started writing is clear. Don't be afraid to made edits, but be sure to read your note over again when you do.
Tip #13
Make your note easy to find
Take some time to consider where to leave your note. If you can't leave it near you, be sure to leave it in an obvious location. Even if you want someone in particular to read your note first, avoid sending it to someone by mail. There are too many things that could go wrong and once you send it, it's gone. Your note could get lost in the mail, or worse, it could reach someone before you can go though with it.
Tip #14
Check your note for flow.
Your note should progress rather then being a loose connection of thoughts and feelings. People reading your note should see that it is going somewhere. If you're having a hard time, start with a sentence or two that sum up the point of the letter, and then end with a summary of the same topic. Every paragraph in between should support that point.
Tip #15
Make sure it's not too long.
There is a reason it's called a suicide note and not a novel. Try to keep it around two or three pages at the most. Avoid the temptation to mention or leave a little note to everyone you know. Not only does that get dull fast but you're certain to leave someone out.